The Department of Computer Science at the University of Cyprus cordially invites you to the Colloquium entitled:
Magnetic Resonance Elastography for Age-Related Dementias
Speaker: Prof. John G. Georgiadis
Idiopathic normal pressure hydrocephalus (NPH), one of the few debilitating dementias afflicting our growing aged population that can be treated, is diagnosed by an invasive test requiring cerebrospinal fluid (CSF) reduction and gait analysis, prior to establishing a permanent shunt. Since there is a significant diagnostic overlap between NPH and other dementias, primarily Alzheimer’s disease, which do not respond to the CSF reduction, enhancing the sensitivity and specificity of the diagnostic evaluation has severe implications for the diagnosis and treatment of NPH. We are utilizing Magnetic Resonance Elastography to assess how the viscoelastic properties of the brain of NPH patients who respond to the treatment differ from those who do not. This project is highly relevant to public health because it has the potential to enhance our ability to diagnose and treat this disease, elucidate its etiology, as well as effectively detect and combat other dementias that will impact approximately 10% of people older than 65 years.
John Georgiadis is currently the R. W. Kritzer Professor of Mechanical Engineering and Bioengineering at the University of Illinois at Urbana-Champaign. He obtained his Dipl. Eng from the National Technical University of Athens, and his MS and PhD from UCLA. Georgiadis’ research expertise lies in the intersection of fluid mechanics & transport phenomena, biomechanics, and Magnetic Resonance Imaging (MRI). The long-term goal of his group is to develop new MRI modalities to improve the quality of life of the elderly. He has used MRI (in vitro) to quantify fluid velocity, diffusion, and temperature fields in complex phantoms, and (in vivo) to map axonal tracts in the human pons and hippocampus, myofiber orientation and fat distribution in skeletal muscle, and to measure perfusion in muscle. Georgiadis has recently led an NIH-funded team to develop and validate the use of Diffusion Tensor Imaging and Magnetic Resonance Spectroscopy to measure muscle quality. The team linked the effect of nutrition and exercise on the histoarchitecture and function of leg muscles in obese older women at risk for disability due to disordered body composition. The current work in Magnetic Resonance Elastography is a natural continuation of the team’s effort to develop new biomarkers for age-related disorders.
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